Scientific Publications

Bcl-2 inhibitor program

Apogossypol derivatives as pan-active inhibitors of antiapoptotic B-cell
lymphoma/leukemia-2 (Bcl-2) family proteins

Apogossypol derivatives as antagonists of antiapoptotic Bcl-2 family proteins

Bcl-2–family proteins and hematologic malignancies: history and future prospects

Bcl-2 antagonist apogossypol (NSC736630) displays single-agent activity in Bcl-2–transgenic mice and has superior efficacy with less toxicity compared with gossypol (NSC19048)

Apoptosis-based therapies for hematologic malignancies

Comparison of pharmacokinetic and metabolic profiling among gossypol, apogossypol and apogossypol hexaacetate

Expanding circle of inhibition: Small-molecule inhibitors of Bcl-2 as anticancer cell and antiangiogenic agents

Comparison of chemical inhibitors of antiapoptotic Bcl-2-family proteins

Rational design and real time, in-cell detection of the proapoptotic activity of a novel compound targeting Bcl-XL

NK cell activator program including CNDO102

Tumor-primed human natural killer cells lyse NK-resistant tumor targets: evidence of a two-stage process in resting NK cell activation